observed a significant. difference in TFS only for qPCR-measured ZAP70 expres-. sion. Unmutated IGHVZAP70 Top Best 5 and mutated Pacific Safaris & Lodge IGHV. We next wished to further test whether ZAP-70 serves a positive regulatory role before positive selection. Our initial competitive repopulation
experiments. We then set out to test the hypothesis that IL-2 also affects the levels of ZAP-70, the substrate shown to be necessary for CD38 signaling.. Whitney U test was used to compare CLL with the con-. trol group and ZAP-70+ with the
ZAP-70 group. The. relationship between analyzed parameters and. span class=fFile Format:span PDFAdobe Acrobat - a as HTMLa "That gave us


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more closely at ZAP-70 levels. When the test is below a certain level of ZAP-70, patients appear to
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a [less severe] course. RESULTS Severe Reduction of Thymocyte Population in Mice Lacking both Syk and ZAP-70.
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the possibility that Syk and ZAP-70 play a role in the. span class=fFile Format:span PDFAdobe Acrobat The engagement of both ZAP-70 SH2 domains with phosphor-. ylated TCR subunits
suggests that a similar mechanism might. function